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    • 专利摘要:
    The subject of the present invention is the oral cosmetic use of a combination of active agents comprising at least one polyunsaturated fatty acid and a carotenoid to improve the quality of the hair and more particularly the quality of the hair at the level of a hair. zone having thrust before said use of association of said assets. This combination of assets may further include, as an additional asset, vitamin E, vitamin C or combinations thereof. The combination of active ingredients is preferably implemented in a cosmetic composition intended for oral administration, such as a dietary supplement.
    公开号:FR3014688A1
    申请号:FR1362462
    申请日:2013-12-12
    公开日:2015-06-19
    发明作者:Nathalie Piccardi
    申请人:Laboratoires Inneov SNC；
    IPC主号:
    专利说明:

    [0001] Composition based on polyunsaturated fatty acid and a carotenoid for oral administration to improve the quality of the hair.
    [0002] Field of the Invention The invention relates to the oral cosmetic use of a combination of polyunsaturated fatty acid and carotenoid active ingredients to improve the quality of the hair along its entire length. STATE OF THE ART The hair is produced in hair follicles consisting of epithelial sheaths of epidermal origin and a hair bulb containing bulbar keratinocytes in a state of permanent division during the growth phases of the hair. This growth is on average 1 to 1.5 cm per month, ie 0.35 mm per day (Vogt A et al., Biology of the hair follicle, Hair growth and Disorders, Springer eds, pp 1-22). Each hair follicle follows its own hair cycle which consists of 3 phases. The follicles are programmed to perform 25 to 30 hair cycles during life. Having healthy and vigorous hair throughout life is sought after by most women and men.
    [0003] For this purpose, there are many formulations of shampoos, conditioners, masks, hair oils, etc., which act directly on the hair or the scalp. Ingested oral food supplements are also used for hair care, for example to reduce hair loss or promote their growth. The scalp has 100,000 to 150,000 hairs. The dermal papilla provides the nutrients necessary for the formation of keratin which is essential for hair growth. Existing food supplements therefore act at the base of the hair. The food supplements available on the market are mainly based on vitamin B and sometimes contain vitamin A, vitamin E or vitamin C. In addition to these vitamins, food supplements generally contain sulfur amino acids and / or zinc . Vitamins B5 and B8 are used for example to prevent hair loss, vitamins B2 and B6 to prevent and treat dandruff and vitamin B3 to stimulate microcirculation. In addition, sulfur-containing amino acids, such as methionine and cysteine, are used to promote hair growth. However, all of these compounds act on the hair growing during the taking of the food compound.
    [0004] There is therefore a need to obtain dietary supplements that improve the quality of the hair along its length, also the hair and hair shaft that were formed well before taking the dietary supplement. The present invention aims to meet this need. Indeed the inventors have surprisingly demonstrated that after 3 months and 6 months of oral administration of at least one carotenoid, vitamin C, vitamin E and at least one polyunsaturated fatty acid, in particular from of fish oil and / or blackcurrant seed oil the quality of the hair is improved on the area of the hair located 6 to 10 centimeters from the scalp, the area of the hair having already grown about 6 to 10 months before taking the dietary supplement.
    [0005] SUMMARY OF THE INVENTION The present invention is therefore based on the discovery by the inventors that the oral administration of at least one carotenoid, vitamin C, vitamin E and at least one fatty acid polyunsaturated, in particular derived from fish oil and / or blackcurrant seed oil, makes it possible to improve the quality of the hair and more particularly the quality of the hair at the level of an area having thrust before the administration orally of at least one carotenoid, vitamin C, vitamin E and at least one polyunsaturated fatty acid, in particular derived from fish oil and / or blackcurrant seed oil.
    [0006] Thus, surprisingly, the inventors have demonstrated that cosmetic compositions intended for oral administration are useful for improving the quality of the hair, and more particularly for increasing the diameter of the fiber and / or the density of the hair. fiber and / or to increase the volume of the hair and / or to improve the quality of the hair fiber, at the level of a zone having thrust before the oral administration of at least one carotenoid, vitamin C, vitamin E and at least one polyunsaturated fatty acid, in particular derived from fish oil and / or blackcurrant seed oil.
    [0007] The inventors have in particular used at least one cosmetic composition that may be in the form of soft capsules which comprises a combination of active agents comprising polyunsaturated fatty acids present in the form of fish oil and blackcurrant seed oil, a caratenoid, vitamin C and vitamin E.
    [0008] The administration of the above composition, in particular at the rate of two capsules per day, makes it possible to improve the quality of the hair and more particularly the quality of the hair at the level of an area having pushed before the administration of said composition. The invention thus relates to the cosmetic use, orally, of an active combination comprising at least one polyunsaturated fatty acid, vitamin C, vitamin E and a carotenoid to improve the quality of the hair, and more particularly to increase the diameter of the fiber and / or the density of the fiber and / or increase the volume of the hair and / or improve the quality of the hair fiber, at the level of an area having thrust before the oral administration of at least one carotenoid, vitamin C, vitamin E and at least one polyunsaturated fatty acid, in particular derived from fish oil and / or blackcurrant seed oil, especially the man and the woman. The invention particularly relates to the above cosmetic use, in which the combination of active ingredients is used in a cosmetic composition suitable for oral administration. The subject of the invention is also a cosmetic composition intended for oral administration comprising: (i) at least one polyunsaturated fatty acid in a content of between 1% and 80% by weight, relative to the total weight of the cosmetic composition (ii) at least one carotenoid in a content of between 0.01% and 6% by weight, relative to the total weight of the composition, (iii) optionally vitamin E in a content of between 0.001% and 10% by weight, relative to the total weight of the composition, (iv) optionally vitamin C in a content of between 0.001% and 30% by weight, relative to the total weight of the composition, and Kit The present invention also has object a kit or cosmetic combination product for simultaneous, separate or spread use over time, comprising a first cosmetic composition comprising a part of the compounds forming the combination of assets as defined above and one of uxième cosmetic composition comprising at least the other part of the compounds forming said association of assets. The present invention also relates to a cosmetic process for improving the quality of the hair, and more particularly the quality of the hair at the level of a zone having a thrust before the oral administration of an association of active ingredients as defined herein. above, comprising the oral administration to an individual of said combination of active ingredients, a cosmetic composition intended for oral administration as defined above, or a kit or cosmetic combination product such as as defined above. DETAILED DESCRIPTION The main subject of the invention is thus the orally cosmetic use of a combination of active agents comprising at least one carotenoid and at least one polyunsaturated fatty acid, in particular derived from fish oil and / or blackcurrant seed oil, to improve the quality of the hair and more particularly to improve the quality of the hair in an area having pushed before the administration of the assets orally, especially in humans or in the woman.
    [0009] In a preferred manner according to the invention, the oral cosmetic use of a combination of active agents comprising at least one carotenoid and at least one polyunsaturated fatty acid, in particular derived from fish oil and / or black currant seed, is characterized in that the improvement of the quality of the hair at the level of a zone having thrust before said use comprises increasing the diameter of the fiber and / or the density of the fiber and / or the improvement of the volume of the hair and / or the improvement of the quality of the hair fiber at a zone having a thrust before the oral administration of the aforementioned composition. By "at a zone having thrust before" is meant to designate according to the invention the hair having grown before the day of the first oral administration of the combination of assets as defined according to the invention. It is known that the hair grows about 1cm every month, after 3 months, this area is defined on the fiber: 3 cm from the scalp to the tip of the hair and preferably from 3 to 10 cm scalp. After 6 months, this zone is defined on the fiber at 6 cm from the scalp to the tip of the hair and preferably 6 to 10 cm from the scalp and even more preferably is 10 cm from the scalp. By "hair over its entire length" is meant according to the invention ranging from scalp to the tip. By "increasing the density" is meant according to the invention a greater number of hair per cm2. Hair density is also measurable with Trichoscan®. With this device, a density of less than 250 hairs per cm2 is considered a low density. A 5% increase in density can be considered clinically significant and visible. By "increasing the diameter of the hair fiber" is meant to designate according to the invention an increase in the number of hair with a diameter greater than 40 pm. 5% of the number of hair with a diameter greater than 40 iam can be considered significant.
    [0010] Density and diameter can also be assessed by measuring the cross section of a lock of hair using a device called a Trichometer [www.haircheck.com; Cohen B. The cross-section thrichometer: a new device for measuring hair, hair loss and hair growth, Dermatol Surg, 2008; 34: 900-911]. By "increasing the volume of the hair" is meant in particular designate according to the invention an increase in the diameter of the hair associated with a decrease in the heterogeneity of the hair diameter, and an increase in density. The heterogeneity of the hair diameter can be measured by means of a binocular loupe, for example by sorting a wick of 50 to 100 cut (or dehaired) hair, classifying it, for example into four categories (very fine, fine). thick and very thick), and calculating the percentage of hair in each category. The heterogeneity of the hair diameter is then evaluated by comparing the evolution of these percentages over time. By "improving the quality of the hair fiber" is meant an increase in the tensile strength of the hair, and / or the prevention and / or the fight against brittle hair. By "preventing and / or fighting against brittle hair, is meant according to the invention an overall improvement of the structure of the hair shaft and in particular the cuticle, the outermost layer of the hair. The quality of the cuticle can be assessed, for example by means of a microscope, noting the presence of tight or disjoint scales, intact scales or no scales and / or broken or missing scales. A 5% decrease in the number of disjunct, broken or missing scales can be considered significant.
    [0011] By "improving the tensile strength of the hair" is meant according to the invention the strength of the hair that can be measured by the tensile test. This measurement of determination of the mechanical tensile properties of the hair can be carried out using a commercial tool, the MTT600 (mini Tensile Tester) from Dia Stron (http://www.diastron.com/). A 5% increase in the force required to break the hair is considered significant. The different parameters as defined above can be evaluated using a multiple choice questionnaire completed by men and / or women in an observational study that can be performed in dermatologists. An effect will be considered significant when at least 50% of men and / or women have perceived a positive effect. Polyunsaturated Fatty Acids For the purposes of the present invention, the term "polyunsaturated fatty acid" means a fatty acid comprising at least two double bonds. It is more particularly long-chain fatty acids, that is to say having at least 14 carbon atoms. The polyunsaturated fatty acids may be in acid form, in the form of triglycerides or in the form of methyl or ethyl esters. The polyunsaturated fatty acids include fatty acids (0-3, fatty acids (0-6 and fatty acids (0-9), characterized by the position of the unsaturation closest to the terminal methyl group, and mixtures thereof. Subsequently, the terms "w" and "omega" are used interchangeably.Polyunsaturated fatty acids having from 18 to 22 carbon atoms, more preferably fatty acids (0-3, (0-), are particularly suitable for the invention. 6 and (0-9.
    [0012] Polyunsaturated fatty acids, omega 6 and omega 3, may be present in the composition at a ratio of between 1/600 and 600/1, especially between 1/400 and 400/1, and preferably between 1/300 and 300/1. .
    [0013] Among the polyunsaturated fatty acids of the (0-6) series, mention may in particular be made of linoleic acid with 18 carbon atoms and two unsaturations or LA (18: 2, (0-6), y-linolenic acid with 18 carbon atoms and three unsaturations or GLA (18: 3, (0-6), dihomogamalinolenic acid with 20 carbon atoms and 3 unsaturations (20: 3, (0-6), arachidonic acid, 5,8,11,14 eicosatetraenoic acid (20: 4, (0-6) and docosatetraenoic acid (22: 4, (0-6).) The polyunsaturated fatty acids of the series (0-3 can in particular be chosen among α-linolenic acid or ALA (18: 3, (0-3), stearidonic acid or SDA (18: 4, (0-3), 5,8,11,14,17- eicosapentaenoic acid or EPA (20: 5, (0-3), 4,7,10,13,16,19-docosaheaxaenoic acid or DHA (22: 6, (0-3), docosapentaenoic acid or DPA ( 22,5, (0-3) and n-butyl-5,11,14-eicosatrienic acid The polyunsaturated fatty acids of the series (0-9 may especially be chosen from oleic acid (18: 1, (0-9) and the acid Rucic acid (22: 1, (0-9).) α-Linolenic acid, linoleic acid, γ-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid, an extract comprising them or combinations thereof. According to a variant of the invention, the polyunsaturated fatty acid (s) considered is (are) used in an isolated form, that is to say after extraction of its (their) (s)) source (s) of origin.
    [0014] The total content of polyunsaturated fatty acid (s) in a composition according to the invention may vary from 1% to 80% by weight, preferably from 5% to 70% by weight, more preferably from 10% to 60% by weight. % by weight, more preferably still from 20% to 50% by weight relative to the total weight of the composition. For example, a composition according to the invention may comprise a total content of polyunsaturated fatty acid (s) of between 35% and 45% by weight. A composition according to the invention, as developed below, may comprise the polyunsaturated fatty acid (s) in a concentration adjusted so that the polyunsaturated fatty acid (s) is (are) (are) administered at a content ranging from 100 mg / day to 1500 mg / day, preferably from 200 mg / day to 700 mg / day, more preferably from 350 mg / day to 550 mg / day. For example, a composition according to the invention may comprise the polyunsaturated fatty acid (s) in a concentration adjusted so that the polyunsaturated fatty acid (s) is (are) administered ( s) at a level ranging from 400 mg / day to 500 mg / day.
    [0015] The source of polyunsaturated fatty acid may be chosen from vegetable oils, for example evening primrose oil, borage oil, blackcurrant seed oil, echium oil, hemp, an extract of the microalgae Schizochytrium sp or their combinations. The plant source of polyunsaturated fatty acid is preferably blackcurrant seed oil. The source of polyunsaturated fatty acid may also be selected from fish oils. Vegetable oils of nuts, hazelnuts, almonds (Juglans regia), coriander and soy (Glycina max), rapeseed (Brassica naptus), chia, flax and fish oils, for example, are rich in fatty acids Polyunsaturated polyunsaturates (0-3) Polyunsaturated fatty acids (0-3 can also be found in zooplankton, crustaceans / molluscs and fish) Fish oils are the main industrial source of EPA and DHA. biomasses of microalgae can also be a raw material for the extraction of polyunsaturated fatty acids (0-3.
    [0016] Thus, a polyunsaturated fatty acid can be used in a combination of active agents according to the invention in the form of at least one oil chosen from evening primrose oil, borage oil and seed oil. of blackcurrant, walnut oil, soybean oil, fish oil, sunflower oil, wheat germ oil, hemp oil, fenugreek oil, oil of echium, argan oil, rice bran oil, sesame oil, almond oil, hazelnut oil, chia oil, linseed oil, olive oil, avocado oil, safflower oil, camelina oil, Inca Inchi oil, passion fruit oil, raspberry seed oil Cranberry Seed Oil, Blueberry Seed Oil, Rubus Chamaemorus Linnaeus Seed Oil, Sea Buckthorn Oil, Cumin Oil, Kiwi Seed Oil, Seed Oil coriander oil, microalgae extract oil, zooplankton extract oil, crustacean extract oil and / or molluscs, or their combinations. The microalgae extract oil is for example an extract oil of Schizochytrium sp. It is preferably a blackcurrant seed oil and / or a fish oil, more preferably a blackcurrant seed oil and a fish oil. A composition according to the invention, as developed below, may comprise an oil and / or an extract and / or a biomass in a content of between 20% and 99% by weight, preferably between 30% and 95% by weight. by weight, more preferably between 50% and 90%, more preferably still between 60% and 85% relative to the total weight of the composition. For example, a composition according to the invention may comprise an oil and / or an extract and / or a biomass in a content of between 80% and 85% by weight relative to the total weight of the composition. A composition according to the invention, as developed below, may comprise an oil and / or an extract and / or a biomass in a concentration adjusted so that said oil and / or extract and / or biomass is administered at a concentration of ranging from 100 mg / day to 5000 mg / day, preferably from 150 mg / day to 3000 mg / day, more preferably from 200 mg / day to 1000 mg / day. For example, a composition according to the invention may comprise an oil and / or an extract and / or a biomass in a concentration adjusted so that said oil and / or extract and / or biomass is administered at a content ranging from 200 mg / ml. day at 500 mg / day.
    [0017] Thus, according to a preferred embodiment, a combination of active agents according to the invention comprises at least one oil selected from a blackcurrant seed oil and / or a fish oil. According to a more preferred embodiment, a combination of active agents according to the invention comprises a blackcurrant seed oil and a fish oil, preferably in a content of between 80% and 85% by weight, for example for a administration at a level ranging from 200 mg / day to 500 mg / day. Additional Assets A combination of assets according to the invention may also include one or more other additional cosmetic active (s). Advantageously, such an additional cosmetic active may be intended to reinforce the desired cosmetic effect as described above. Of course, those skilled in the art will take care to choose the additional assets and their amount so that the advantageous properties of the composition according to the invention are not, or not substantially impaired by the addition envisaged. As additional active usable, mention may be made of: vitamins other than vitamin E such as vitamin A, at least one vitamin of group B, for example vitamin B1 (also called thiamine), vitamin B2 (also called Riboflavin), vitamin B3 (also called niacin or vitamin PP), vitamin B5, vitamin B6, vitamin B8, vitamin B9 and vitamin B12. antioxidants, such as curcuminoids; carotenoids, especially chosen from (3-carotene, astaxanthin, zeaxanthin, lutein or compounds containing them, such as goji berries, polyphenol compounds, flavonoids such as catechins, proanthocyanidins, anthocyanins, OPC (procyanidolic oligomers), ubiquinones, coffee extracts containing polyphenols and / or diterpenes, chicory extracts, ginkgo biloba extracts, proanthocyanidin-rich grape extracts, pepper extracts, soy extracts cocoa, pomegranate, Emblica, CoenzymeQ10, selenium, minerals, calcium, magnesium, copper, iron, iodine, manganese, selenium, chromium (III), sugars, amino acids, especially sulfur-containing amino acids, such as glutathione precursors, the amino acids of selenium, citrulline, phytosterols, resveratrol, hesperidin, neohesperidin, orthosilicic acid, monomethylsilanetriol, and mixtures thereof. In another particularly advantageous embodiment of the invention, the combination of active agents comprises, as additional active ingredient, at least one compound chosen from vitamin C, vitamin E or a carotenoid. The combination of active ingredients may for example comprise, as additional active ingredient, at least two compounds chosen from vitamin C, vitamin E or a carotenoid, or these three compounds.
    [0018] Vitamins C and E According to another of its aspects, the present invention relates to a combination of active agents comprising at least one polyunsaturated fatty acid and at least one other vitamin selected from vitamin C and vitamin E.
    [0019] Vitamin E is preferably in the form of tocopherol acetate. According to yet another of its aspects, the present invention relates to a combination of active agents comprising at least one fish oil comprising at least one polyunsaturated fatty acid, vitamin C and vitamin E. Preferably, an association of active ingredients according to the invention comprises at least one fish oil comprising at least one polyunsaturated fatty acid, vitamin C, and also vitamin E. According to another of its aspects, the present invention relates to a combination of active agents comprising at least one blackcurrant seed oil comprising at least one polyunsaturated fatty acid, vitamin C and vitamin E. Preferably, an active combination according to the invention comprises at least one blackcurrant seed oil comprising at least one less a polyunsaturated fatty acid, vitamin C, and also vitamin E. According to another of its aspects, the present invention relates to a combination of active ingredients comprising at least one The composition according to the invention, as developed below, may comprise vitamin C in a content of between 0.001% and 30% by weight of vitamin C and a fish oil, vitamin E and vitamin C. weight, preferably between 0.01% and 25% by weight, and more preferably between 0.1% and 20% by weight, more preferably between 1% and 15% by weight relative to the total weight of the composition. For example, a composition according to the invention may comprise vitamin C in a content of between 2% and 3% by weight relative to the total weight of the composition. A composition according to the invention, as developed hereinafter, may comprise vitamin C in a concentration adjusted to be administered at a level of from 5 mg / day to 100 mg / day, preferably from 10 to 10 mg / day. mg / day to 90 mg / day, more preferably 20 mg / day to 80 mg / day. For example, a composition according to the invention may comprise vitamin C in a concentration adjusted to be administered at a content ranging from 25 mg / day to 30 mg / day. A composition according to the invention, as developed below, may comprise vitamin E in a content of between 0.001% and 10% by weight, preferably between 0.01% and 10% by weight, and more preferably between 0.1% and 5% by weight, more preferably still between 0.2% and 2% by weight relative to the total weight of the composition. For example, a composition according to the invention may comprise vitamin E in a content of between 0.4% and 0.5% by weight relative to the total weight of the composition. A composition according to the invention, as developed below, may comprise vitamin E in a concentration adjusted to be administered at a content ranging from 0.1 mg / day to 20 mg / day, preferably from 1 mg / day to 15 mg / day, more preferably from 2 mg / day to 12 mg / day.
    [0020] For example, a composition according to the invention may comprise vitamin E in a concentration adjusted to be administered at a content ranging from 4 mg / day to 6 mg / day. Carotenoid A preferred combination of actives according to the invention comprises at least one carotenoid. In the context of the present invention, the term "carotenoid" means both a carotenoid with provitamin A activity and a carotenoid without provitamin A activity. Of course according to the invention, the carotenoid may be a mixture of carotenoids with activity. Provitamin A and carotenoids without provitamin A activity. This mixture may be in any proportion. According to the invention, the carotenoid with provitamin A activity can be a mixture of carotenoids with provitamin A activity. This mixture can be in any proportion. Among the carotenoids with provitamin A activity, mention may be made, for example, of β-carotene or α-carotene, preferably p-carotene, According to the invention, the carotenoid without provitaminic activity A can be a mixture This mixture may be in any proportion Among the carotenoids without provitaminic activity A, there may be mentioned, for example, zeaxanthin, cryptoxanthin, lutein or lycopene.
    [0021] More particularly, the carotenoid used in the context of the present invention is lycopene. In other words, the carotenoid present in the combination of actives of the present invention comprises, or even consists of, lycopene.
    [0022] A carotenoid according to the invention may also be astaxanthin. The carotenoid used according to the invention may be of natural or synthetic origin. By natural origin is meant the carotenoid, in pure form or in solution whatever its concentration in said solution, obtained from a natural element such as a plant extract. For example, when the carotenoid is lycopene, a tomato extract can be used more particularly. Thus, according to a preferred embodiment of the invention, the carotenoid used in an association according to the invention is lycopene, preferably in a tomato extract, more preferably a tomato extract rich in lycopene.
    [0023] A tomato extract rich in lycopene for example comprises at least 5% of lycopene, more preferably at least 7% of lycopene, more preferably at least 10% of lycopene by weight relative to the total weight of the extract. A tomato extract rich in lycopene advantageously comprises at least 10% of lycopene, by weight relative to the total weight of the extract.
    [0024] By "synthetic origin" is meant lycopene, in its pure state or in solution whatever its concentration in said solution, obtained by chemical synthesis. Lycopene can be used in the context of the present invention may be in cis or trans chemical form. When the carotenoid is of natural origin, it can be obtained from plant material derived from whole plants grown in vivo or from in vitro culture. By "cultivated in vivo" is meant any culture of conventional type that is to say in soil in the open air or in the greenhouse, or above ground. By "in vitro culture" is meant all the techniques known to those skilled in the art that artificially allow the production of a plant or a part of a plant. The selection pressure imposed by the physicochemical conditions during the growth of the plant cells in vitro makes it possible to obtain standardized plant material that is available throughout the year, unlike plants grown in vivo. Preferably, according to the invention, a plant derived from an in vivo culture is used. Any extraction method known to those skilled in the art can be used to prepare the carotenoid used according to the invention. Very preferably, in the case of lycopene, a tomato extract rich in lycopene is used. Lycopene is also present in melon, guava and grapefruit.
    [0025] Lycopene can be in alcoholic solution, in particular ethanolic solution. The carotenoid may also be in lipid or lipoalcoholic solution. Lycopene can be in aqueous suspension. For this, one can use hydrodispersible forms, cold or hot.
    [0026] Any other more complex ingredient based on lycopene can also be used for the implementation of the invention. Thus, the term more complex ingredient for example a primary composition comprising lycopene and a whey protein. This primary composition is described in particular in WO 01/91588. This primary composition is also known as lactolycopene. It has the advantage of increasing the bioavailability of lycopene and / or of being easily formulated in food supplements (sachet, capsule, tablet, sugar-coated, soft capsule, etc.) forms. Lactolycopene may in particular be sold by Indena. The amount of extract that can be used according to the invention is, of course, a function of the desired effect and can therefore vary to a large extent. The total content of carotenoid (s), preferably lycopene, in a composition according to the invention may vary from 0.01% to 6% by weight, preferably from 0.02% to 4% by weight, more preferably from 0.05% to 3% by weight, more preferably still from 0.07% to 2% by weight, relative to the total weight of the composition.
    [0027] For example, a composition according to the invention may comprise a total content of carotenoid (s), preferably lycopene, of between 0.09% and 0.1% by weight relative to the total weight of the composition. A composition according to the invention, as developed below, may comprise at least one carotenoid, preferably lycopene, in a total concentration of carotenoid (s) adjusted for administration at a content ranging from 0.1 mg / ml. day at 10 mg / day, preferably from 0.5 mg / day to 8 mg / day, more preferably from 0.8 mg / day to 6 mg / day. For example, a composition according to the invention may comprise at least one carotenoid, preferably lycopene, in a concentration adjusted to be administered at a content ranging from 1 mg / day to 1.5 mg / day. Thus, an active combination according to the invention advantageously comprises at least one oil comprising at least one polyunsaturated fatty acid, and isolated lycopene and / or a lycopene-rich extract.
    [0028] According to a preferred embodiment, an association of active ingredients according to the invention comprises fish oil and / or blackcurrant seed oil, and a tomato extract. According to a still preferred embodiment, a combination of active ingredients according to the invention comprises fish oil, blackcurrant seed oil, vitamin E and a tomato extract. Preferably, an active combination according to the invention comprises, in addition to at least one polyunsaturated fatty acid, lycopene, vitamin C and / or vitamin E, preferably vitamin C and vitamin E.
    [0029] Antioxidant Agent A combination of active ingredients according to the invention may comprise, in addition to at least one polyunsaturated fatty acid and a carotenoid, an antioxidant agent other than carotenoids.
    [0030] Antioxidants are known to those skilled in the art. The antioxidants may for example be selected from curcuminoids; polyphenol compounds, flavonoids such as catechins; proanthocyanidins, anthocyanins, OPCs (procyanidolic oligomers); ubiquinones; coffee extracts containing polyphenols and / or diterpenes; chicory extracts; ginkgo biloba extracts; grape extracts rich in proanthocyanidins; chili extracts; soy extracts; Cocoa ; the grenade ; the Emblica; CoenzymeQ10; selenium. Anti-inflammatory agent A combination of active agents according to the invention may comprise, in addition to at least one polyunsaturated fatty acid, an anti-inflammatory agent. Anti-inflammatory agents are known to those skilled in the art. An anti-inflammatory agent according to the invention may be chosen from flavonoids such as catechins, proanthocyanidins, anthocyanins, procyanidolic oligomers (OPC), flavanones, for example hesperidin. In a particular embodiment, the combination of active ingredients does not include an anti-inflammatory agent.
    [0031] Probiotic and Prebiotic Microorganism According to a particular embodiment, a composition of the invention may further comprise at least one probiotic microorganism, at least one prebiotic or combinations thereof.
    [0032] Specific examples of probiotic microorganisms suitable for the invention are microorganisms of the genus Bifidobacterium, such as Bifidobacterium adolescentis, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium pseudocatenulatum, Lactobacillus acidophilus (LC1, NCFB 1748); microorganisms of the genus Lactobacillus, such as Lactobacillus amylovorus, Lactobacillus casei (Shirota), Lactobacillus rhamnosus (GG strain), Lactobacillus brevis, Lactobacillus crispatus, Lactobacillus delbrueckii (subsp. bulgaricus, lactis), Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus gallinarum, Lactobacillus Gasseri, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus alimentarius, Lactobacillus curvatus, Lactobacillus casei subsp. casei, Lactobacillus sake, microorganisms of the genus Lactococcus, such as Lactococcus lactis, Lactococcus lactis subspp. lactis or cremoris, microorganisms of the genus Enterococcus, such as Enterococcus faecalis or Enterococcus faecium, microorganisms of the genus Leuconostoc, such as Leuconostoc mesenteroides subsp. dextranicum, microorganisms of the genus Pediococcus, such as Pediococcus acidilactici, microorganisms of the genus Sporolactobacillus, such as Sporolactobacillus inulinus, microorganisms of the genus Streptococcus, such as Streptococcus salvarius subsp. thermophilus, Streptococcus thermophilus, microorganisms of the genus Staphylococcus, such as Staphylococcus carnosus, Staphylococcus xylosus, microorganisms of the genus Saccharomyces, such as Saccharomyces cerevisiae or Saccharomyces boulardii, microorganisms of the genus Bacillus, such as Bacillus cereus var. toyo, Bacillus subtilis, Bacillus coagulans, Bacillus licheniformis, microorganisms of the genus Escherichia, such as Escherichia coli strain nissle, microorganisms of the genus Propionibacterium, such as Propionibacterium freudenreichii, or combinations thereof. The microorganisms may be formulated as powders, i.e., in a dry form, or as suspensions or solutions.
    [0033] More particularly, it may be a probiotic microorganism selected from microorganisms of the genus Lactobacillus sp. and / or Bifidobacterium sp., one of their fractions and / or one of their metabolites. As an illustration of these microorganisms, there may be mentioned more particularly Lactobacillus johnsonii, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium animalis, Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, or their combinations. The most suitable species are Lactobacillus johnsonii, Lactobacillus paracasei, Bifidobacterium adolescentis, Bifidobacterium longum or Bifidobacterum Lactis NCC 2818 (also designated Bb12 ATCC 27536) respectively deposited according to the Budapest Treaty with the Institut Pasteur (28 rue du Docteur Roux, F75024 Paris cedex 15) the 30/06/92, 12/01/99, 15/04/99, 15/04/99, 07/06/05 under the following designations CNCM I-1225, CNCM I-2116, CNCM 1- 2168, CNCM 1-2170 and CNCM I-3446, and the species Bifidobacterium longum (BB536). The strain of Bifidobacterium lactis CNCM I-3446 can be obtained from Hansen (Hansen A / S Chr., 10-12 Boege Alle, PO Box 407, DK-2970 Hoersholm, Denmark). According to a particular embodiment of the invention, the composition comprises at least two different microorganisms, including probiotics, and / or metabolites and / or fractions thereof. These microorganisms may differ by their nature for example bacterium and fungus, or by their family, their genus, their species, or only by their stock. The prebiotics that are suitable for the invention may be chosen from oligosaccharides produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose, inulin and gums, for example of the acacia type. or a mixture thereof. More particularly, the oligosaccharide comprises at least one fructooligosaccharide. More particularly, this prebiotic may comprise a mixture of fructo-oligosaccharide and inulin. In a particular embodiment, the combination of active ingredients does not include a probiotic and / or prebiotic microorganism. Cosmetic composition for oral administration and kits According to one aspect of the invention, an active combination according to the invention can be implemented in a cosmetic composition suitable for oral administration. The present invention particularly relates to a cosmetic composition adapted for oral administration comprising an active combination as defined above. By "cosmetic composition" is meant, for example, a nutritional composition, for example a food supplement, comprising at least one combination of active agents according to the invention.
    [0034] The terms "nutritional composition", "nutraceutical composition" or "cosmeceutical composition" are here synonymous. By "dietary supplement" is meant here a foodstuff whose purpose is to supplement the normal diet and is a concentrated source of nutrients, that is to say vitamins and / or minerals, and / or of other substances having a nutritional or physiological effect, alone or in combination, marketed in the form of doses, namely the forms of presentation such as capsules, lozenges, tablets, soft capsules, pills and other similar forms, as well as sachets of dilutable powder, ampoules of liquid, vials with a dropper and other similar forms of liquid or beverage preparations.
    [0035] A preferred cosmetic composition according to the invention is a dietary supplement. A preferred cosmetic composition according to the invention intended for oral administration comprises: at least one polyunsaturated fatty acid, the total content of polyunsaturated fatty acid being between 1% and 80% by weight, preferably between 5% and 70% by weight; % by weight, more preferably between 10% and 60% by weight, more preferably between 20% and 50% by weight, - at least one cartenoid, the total carotenoid content being between 0.01% and 6% by weight preferably between 0.02% and 4% by weight, more preferably between 0.05% and 3% by weight, more preferably between 0.07% and 2% by weight, - optionally vitamin E in a certain amount. between 0.001% and 10% by weight, preferably between 0.01% and 10% by weight, more preferably between 0.1% and 5% by weight, more preferably between 0.2% and 2% by weight, optionally, vitamin C in a content of between 0.001% and 30% by weight, preferably between 0.01% and 25% by weight, more preferably between 0.1% and 20% by weight, more preferably between 1% and 15% by weight, and the percentages being given by weight relative to the total weight of the cosmetic composition. Such a cosmetic composition suitable for oral administration, preferably a dietary supplement, may have the following contents: Active% by weight relative to the total weight of the composition Polyunsaturated fatty acid (s) 35 to 37 (of which Omega 3 and omega 6) Vitamin C 2.4 to 2.5 Vitamin E 0.4 to 0.5 Carotenoid (s) preferably Lycopene) (from 0.09 to 0.10 A composition according to the invention comprises a Physiologically or cosmetically acceptable vehicle A combination of active ingredients and a composition according to the invention allow, by their oral administration, to improve the quality of the hair.The invention does not relate to the therapeutic field. The combination of active agents in accordance with the invention or the composition in accordance with the invention is administered orally.The combinations of active ingredients and compositions according to the invention, intended for oral administration, may in particular comprise end all or only part of the daily dose. In the case of compositions suitable for oral administration, the use of an ingestible carrier is preferred. The unmanageable support may be of various nature depending on the type of composition considered. For ingestion, many embodiments of oral compositions and in particular dietary supplements are possible. The formulation of such compositions may be carried out by any conventional method known to those skilled in the art. Thus, a composition according to the invention may preferably take the form of a dragee, a capsule, a suspension, a gel, an emulsion, an oral solution, a tablet swallowing or chewing, a capsule, including a soft or hard capsule, a granule dissolve, a syrup, a tablet or a drinkable ampoule. It can preferably be in the form of a capsule, soft or hard, preferably in the form of a soft capsule.
    [0036] In particular, an association of active agents according to the invention can be implemented in all forms of food supplements or compacted powders or not. The powders can be diluted with water or in soda. According to a preferred embodiment, a composition according to the invention administered orally can be formulated in the form of a dragee, a capsule, a gel, an emulsion, a tablet, a capsule, a hydrogel or a compacted powder. no, suspension or liquid solution. Oral compositions may be either in anhydrous form or in aqueous form. An association of active agents according to the invention may be formulated with the usual excipients for such oral compositions, such as food supplements, namely in particular fatty and / or aqueous components, humectants, thickeners, preservatives, agents and the like. texture, flavor and / or coating, antioxidants, preservatives and dyes customary in the field of food. Of course, those skilled in the art will take care to choose the possible excipients and formulators and / or their quantity in such a way that the advantageous properties of the combination according to the invention or of the composition comprising the combination according to the invention are not or not substantially impaired by the addition envisaged.
    [0037] The formulating agents and excipients for oral composition, and especially for food supplements, are known in this field and are not the subject of a detailed description here. The invention also relates to a kit or a cosmetic combination product for simultaneous, separate or spread over time use, preferably a food supplement, comprising a first composition comprising a part of the compounds forming the combination of active ingredients according to the invention. invention and a second composition comprising at least the other part of the compounds forming said combination of assets.
    [0038] This complement may be formulated in such a way that the two compositions are in the same forms or in different forms, for example chosen from those mentioned above. Such a kit may in particular be presented in one and the same package. Cosmetic use of the combination of active principles or a composition comprising them The present invention particularly relates to the cosmetic use, orally, of an active combination as defined above comprising at least one acid polyunsaturated fat and at least one carotenoid, to improve the quality of the hair and more particularly the quality of the hair at a zone having thrust before said use. In particular, the present invention relates to the use as defined above, wherein said at least one polyunsaturated fatty acid is used in the form of at least one oil chosen from evening primrose oil, oil of borage, blackcurrant seed oil, walnut oil, soybean oil, fish oil, sunflower oil, wheat germ oil, hemp oil, lemon fenugreek oil, echium oil, argan oil, rice bran oil, sesame oil, almond oil, hazelnut oil, chia, linseed oil, olive oil, avocado oil, safflower oil, camelina oil, raspberry seed oil, cranberry seed oil, bilberry seed oil, Rubus chamaemorus Linnaeus seed oil, sea buckthorn oil, cumin oil, kiwi seed oil, coriander oil, olive oil microalgae extract, zooplankton extract oil, crustacean extract oil and / or m olluscs, or their combinations.
    [0039] In particular, the present invention relates to the use as defined above, wherein said at least one polyunsaturated fatty acid is an omega 3 and / or an omega 6. Preferably omega 3 is chosen from the acid 5,8,11,14,17-eicosapentaenoic acid, 4,7,10,13,16,19-docosahéxaenoic acid, α-linolenic acid, stearic acid or a mixture thereof. Preferably omega 6 is chosen from γ-linolenic acid and / or linolenic acid. In an advantageous embodiment, the present invention relates to the use as defined above, wherein said at least one polyunsaturated fatty acid is used in the form of a blackcurrant seed oil and / or a fish oil and / or said carotenoid is lycopene. In a particularly advantageous embodiment, the present invention relates to the use as defined above, characterized in that the combination of active ingredients comprises, as additional active ingredient, at least one compound chosen from a vitamin or their combinations and preferably vitamin C and / or vitamin E. The subject of the present invention is in particular the use as defined above, in which the combination of active ingredients is used within a composition cosmetic adapted for oral administration.
    [0040] The contents are variable according to the form of the cosmetic composition in which is implemented the combination of assets according to the invention. The contents in the cosmetic composition, the shape of the cosmetic composition and the daily doses administered are in particular as defined above. It is understood in the context of the present invention that "oral cosmetic use" covers the use of orally administered compositions, these compositions being for example in the form of a food supplement. These compositions produce an effect on the level of the hair, in terms of aesthetics and comfort, or beauty, for example in order to protect it, to maintain it in good condition, and especially to embellish it, by improving The invention also relates to a cosmetic method for improving the quality of the hair and more particularly the quality of the hair at a zone having pushed before the implementation of said method, comprising the administration orally to an individual of an active combination as defined above, a cosmetic composition for oral administration as defined above or a kit or combination product such as defined above. The methods according to the invention have the characteristics of cosmetic processes, particularly since they make it possible to improve the aesthetics of the hair. In addition, an association of active ingredients or a composition such as for example a food supplement according to the invention can be used daily for several months, without a medical prescription. The present invention is therefore clearly outside the therapeutic field. Advantageously, the application of a method of the invention confers the advantages indicated above as being associated with the implementation of an association of active ingredients or a composition according to the invention, and may in particular increase it. the diameter of the fiber and / or increase the density of the fiber and / or increase the volume of the hair and / or improve the quality of the hair fiber.
    [0041] A cosmetic process according to the invention can be implemented, in particular by administering a cosmetic composition as defined above. A method of the invention may be implemented daily for example, for example for example a single administration per day or administration twice a day, for example once in the morning and once in the evening, or three times a day, especially at each meal. A cosmetic process according to the invention can be implemented, for example by daily administration of a composition formulated for example in the form of a dragee, capsule, suspension, gel, emulsion, oral solution, tablet to be swallowed or chewable, capsule, in particular soft or hard capsule, granule to dissolve, syrup, tablet or drinkable ampoule, in appropriate quantity and number, according to their shape. An effective amount of an active combination according to the invention may be administered in a single dose per day or in divided doses over the day, for example two to three times a day.
    [0042] A method according to the invention may advantageously comprise a single administration. A cosmetic process may be implemented over a period of time ranging from one week to several weeks, or even several months, this period may also be repeated after periods of non-treatment, for several months or even years. For example, the administration of an asset combination according to the invention may be carried out twice a day, generally over an extended period of at least four weeks, or even four to fifteen weeks, including or not one or more periods of interruption or being repeated after a period of interruption. The ingredients are mixed, before they are shaped, in the order and under conditions easily determined by those skilled in the art. Thus, the uses and / or cosmetic processes according to the invention make it possible to improve the quality of the hair, in particular in men or women. In the description and examples which follow, the ranges of values denoted as "between ... and ..." include the specified lower and upper bounds. Other characteristics and advantages of the invention will emerge more clearly from the examples which follow, given by way of illustration and not limitation. Examples: Example 1: Oral composition in soft capsule form The oral composition has the formula given in the following table: Ingredients Amount ingredient Percentage of active ingredient (in mg / capsule) (by weight relative to weight total off-capsule composition) Fish oil 230.00 12.62 (polyunsaturated fatty acids) Blackcurrant seed oil 230.00 23.98 (polyunsaturated fatty acids) Vitamin E 4.10 0.43 Vitamin C 19.50 2,46 Tomato extract 5,50 0,097 (lycopene) Excipients: Glycerol monostearate 30,03 Beeswax 10,00 Soya lecithin 10,00 Calculation of the fatty acid distribution of the oils used: (1) Fish oil: One soft capsule provides 71.3 mg of omega 3 including: - 34.5 mg of EPA (5,8,11,14,17-eicosapentaenoic acid) (omega 3), - 20.7 mg DHA (4,7,10,13,16,19-docosaheaxaenoic acid) (omega 3). (2) Blackcurrant seed oil: A soft capsule provides 135.47 mg of polyunsaturated fatty acids including: - 80.73 mg of LA (linolenic acid) (omega 6), - 26.91 mg of GLA (y acid) -linolenic) (omega 6), - 22.77 mg of ALA (α-linolenic acid) (omega 3), - 5.06 mg of SDA (stearidonic acid) (omega 3).
    [0043] The soft capsule has for example the following formula: Capsule Fish gelatin 127.776 Glycerol 56.893 Iron oxide 2.051 Titanium dioxide 2.921 Purified water 21.082 A soft capsule according to the invention can be prepared in the following manner. Fish oil, blackcurrant seed oil, vitamin E, vitamin C, tomato extract, and excipients are mixed in the presence of nitrogen. The mixture is then homogenized and then encapsulated in the soft capsule consisting of fish gelatin, glycerol, iron oxide, titanium dioxide and purified water. The dosage is for example from 1 to 4 soft capsules per day, preferably 2 soft capsules / day. This composition makes it possible in particular: - the limitation of hair loss, in particular by promoting the anchoring of the hair, - the improvement of the growth of the hair fiber, in particular by participating in the normal growth of the hair and promoting the thickness of the hair, in particular by the growth of thick hair, - improvement of the volume of the hair, in particular by promoting the capillary abundance, by increasing the capillary mass and the density of the hair, by increasing the diameter of the hair , by preventing and / or limiting the formation of fine hair, Example 2: clinical results One hundred and eighteen women participated in this study and were randomized into two groups: one group receiving the nutritional supplement (79 subjects, including 40 postmenopausal women) and a control group without nutritional supplementation (39 subjects, including 19 postmenopausal women).
    [0044] These women were between 18 and 65 years of age, had a severity score of Ludwig's Grade I hair loss and complained of a loss of volume. Women with short hair (<5 cm) and telogen phase hair> 30% were not included in the cohort. Women in the supplemented group ingested for six months two soft capsules as defined in Example 1 per day. The thickness of a lock of hair predefined at the start of the study was evaluated at TO, T3 months and T6 months at a distance of 10 cm from the scalp, that is to say at the level of a zone having push before taking the dietary supplement. This wick has been identified by a clip for hair extensions, so it is always the same wick that was measured throughout the study. This measurement was performed using a commercially available device and patented the Trichometer [www.haircheck.com; Cohen B. The cross-section thrichometer: a new device for measuring hair, hair loss and hair growth, Dermatol Surg, 2008; 34: 900-911]. This technology is based on the fact that the density and diameter of the hair determines the mass of the hair, and that the measurement of the cross section of a lock of hair reflects the density and the diameter of the hair.
    [0045] The measurement of the cross section is expressed according to an index or "Trichometer index" (mm2 of hair / cm2 of skin x 100). The higher the Trichometer index, the more the hair mass increases. The evolutions of the "Trichometer index" in the supplemented group and the control group are reported in Table X. Table X: "Trichometer index" evolutions at a distance of 10 cm from the scalp The values of the "Trichometer index" do not vary in the control group without supplementation. On the other hand, quite unexpectedly, the "Trichometer index" increases by 3.3% and 6.6% after respectively 3 and 6 months of intake of the food supplement. These increases are statistically significant.
    [0046] In other words, taking the dietary supplement for a minimum of three months increases the mass of the hair, hair that has already grown before taking the food supplement. Intra-group comparison (p-values) COMPOSITION TO T3 63.10 ± 16.23 T3 / TO T6 / TO AS DESCRIBED 59.20 ± 15.93 61.16 ± 16.49 S, p <0.001 S, p <0.001 IN EXAMPLE 1 CONTROL 63.13 ± 15.81 62.15 ± 16.08 61.21 ± 15.87 NS, p = 0.359 NS, Inter-group comparison (p-values) Comparison of evolutions (p-values) COMPOSITION AS DESCRIBED IN EXAMPLE 1 vs CONTROL NS, p = 0.208 S, p = 0.008 S, p <0.001
    权利要求:
    Claims (15)
    [0001]
    REVENDICATIONS1. Cosmetic use, orally, of a combination of active ingredients comprising at least one polyunsaturated fatty acid and at least one carotenoid, for improving the quality of the hair and more particularly the quality of the hair at the level of a zone having a thrust before said use of association of said assets.
    [0002]
    2. Use according to claim 1, wherein said at least one polyunsaturated fatty acid is used in the form of at least one oil chosen from evening primrose oil, borage oil, coconut oil and cassis, walnut oil, soybean oil, fish oil, sunflower oil, wheat germ oil, hemp oil, fenugreek oil, echium, argan oil, rice bran oil, sesame oil, almond oil, hazelnut oil, chia oil, linseed oil, lemon olive oil, avocado oil, safflower oil, camelina oil, raspberry seed oil, cranberry seed oil, bilberry seed oil, lemon seed oil of Rubus chamaemorus Linnaeus, sea buckthorn oil, cumin oil, kiwi seed oil, coriander oil, microalgae extract oil, olive oil zooplankton extract, crustacean extract oil and / or molluscs, or combinations thereof.
    [0003]
    3. Use according to claim 2, characterized in that said at least one polyunsaturated fatty acid is used in the form of a blackcurrant seed oil and / or a fish oil.
    [0004]
    4. Use according to claim 1, characterized in that said at least one polyunsaturated fatty acid is an omega 3 and / or an omega 6.
    [0005]
    5. Use according to one of claims 1 to 4, characterized in that said at least one carotenoid is lycopene, preferably in the form of a tomato extract rich in lycopene.
    [0006]
    6. Use according to one of claims 1 to 5, characterized in that the combination of assets comprises, as additional asset, vitamins, especially vitamin C and / or vitamin E, preferably of vitamin C and vitamin E.
    [0007]
    7. Use according to one of claims 1 to 6, wherein the combination of active is carried out in a cosmetic composition suitable for oral administration.
    [0008]
    8. Use according to claim 7, wherein said composition is in the form of a dragee, a capsule, a suspension, a gel, an emulsion, an oral solution, a swallowing or chewable tablet, capsule, dissolving granule, syrup, tablet or drinkable ampoule.
    [0009]
    9. Use according to claim 5 or 6, wherein said at least one polyunsaturated fatty acid is present in a content of between 1% and 80% by weight relative to the total weight of the cosmetic composition. 15
    [0010]
    10. Use according to one of claims 7 to 9, characterized in that the carotenoid is present in a content of between 0.01% and 6% by weight relative to the total weight of the cosmetic composition.
    [0011]
    11. Use according to one of claims 1 to 10, characterized in that the improvement of the quality of the hair includes increasing the diameter of the fiber and / or increasing the density of the fiber and / or increasing the volume of the hair and / or improving the quality of the hair fiber.
    [0012]
    12. Cosmetic composition intended for oral administration comprising: at least one polyunsaturated fatty acid, the total content of polyunsaturated fatty acid being between 1% and 80%, at least one carotenoid, the total content of carotenoid being between 0.01% and 6%, optionally vitamin E in a content of between 0.001% and 10%, optionally vitamin C in a content of between 0.001% and 30%, and the percentages being given. by weight relative to the total weight of the cosmetic composition. 10
    [0013]
    13. Kit or cosmetic combination product for simultaneous, separate or spreading use comprising a first cosmetic composition comprising a part of the compounds forming the active combination as defined in any one of claims 1 to 6 and a second cosmetic composition comprising at least the other part of the compounds forming said association of active ingredients.
    [0014]
    14. A cosmetic process for improving the quality of the hair and more particularly the quality of the hair at a zone having a push before the implementation of said method comprising the oral administration to an individual of a combination of active agents as defined in one of claims 1 to 5, a cosmetic composition intended for oral administration as defined in one of claims 7 to 12 or a kit or a combination product cosmetic as defined in claim 13.
    [0015]
    15. The method of claim 14, characterized in that the improvement of the quality of the hair includes increasing the diameter of the fiber and / or increasing the density of the fiber and / or increasing the volume of hair and / or improvement of the quality of the hair fiber.
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    同族专利:
    公开号 | 公开日
    US20170000705A1|2017-01-05|
    FR3014688B1|2016-12-16|
    JP2017503851A|2017-02-02|
    WO2015087277A1|2015-06-18|
    CA2932049A1|2015-06-18|
    EP3082468A1|2016-10-26|
    CN105916391A|2016-08-31|
    KR20160096158A|2016-08-12|
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    法律状态:
    2015-11-10| PLFP| Fee payment|Year of fee payment: 3 |
    2016-02-19| CD| Change of name or company name|Owner name: NUTRICOS TECHNOLOGIES, FR Effective date: 20160118 |
    2016-02-19| CA| Change of address|Effective date: 20160118 |
    2016-11-11| PLFP| Fee payment|Year of fee payment: 4 |
    2017-11-13| PLFP| Fee payment|Year of fee payment: 5 |
    2019-11-15| PLFP| Fee payment|Year of fee payment: 7 |
    2020-11-12| PLFP| Fee payment|Year of fee payment: 8 |
    2021-11-09| PLFP| Fee payment|Year of fee payment: 9 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1362462A|FR3014688B1|2013-12-12|2013-12-12|COMPOSITION BASED ON POLYUNSATURATED FATTY ACID AND CAROTENOID FOR ORAL ADMINISTRATION TO ENHANCE THE QUALITY OF THE HAIR|FR1362462A| FR3014688B1|2013-12-12|2013-12-12|COMPOSITION BASED ON POLYUNSATURATED FATTY ACID AND CAROTENOID FOR ORAL ADMINISTRATION TO ENHANCE THE QUALITY OF THE HAIR|
    JP2016558439A| JP2017503851A|2013-12-12|2014-12-11|Composition based on polyunsaturated fatty acids and carotenoids for improving the quality of hair for oral administration|
    CA2932049A| CA2932049A1|2013-12-12|2014-12-11|Composition based on a polyunsatured fatty acid and on a carotenoid, for oral administration, for improving hair quality|
    PCT/IB2014/066807| WO2015087277A1|2013-12-12|2014-12-11|Composition based on a polyunsatured fatty acid and on a carotenoid, for oral administration, for improving hair quality|
    EP14830631.9A| EP3082468A1|2013-12-12|2014-12-11|Composition based on a polyunsatured fatty acid and on a carotenoid, for oral administration, for improving hair quality|
    CN201480073602.8A| CN105916391A|2013-12-12|2014-12-11|Composition based on a polyunsatured fatty acid and on a carotenoid, for oral administration, for improving hair quality|
    KR1020167018215A| KR20160096158A|2013-12-12|2014-12-11|Composition based on a polyunsatured fatty acid and on a carotenoid, for oral administration, for improving hair quality|
    US15/104,117| US20170000705A1|2013-12-12|2014-12-11|Composition based on a polyunsaturated fatty acid and on a carotenoid, for oral administration, for improving hair quality|
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